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Blog · Prostate cancer

Free PSA/total PSA ratio of 0.28. Is there any risk?

Carmen Reis asks: Free PSA/total PSA ratio of 0.28. Is there any risk? The free/total PSA ratio is a parameter widely...

By Dr. Bruno Benigno · Uro-oncologist · CRM-SP 126.265Published on June 3, 20191 min read

This article was translated from the original Portuguese. Português

What is the PSA ratio?

Carmen Reis asks:

Free PSA/total PSA ratio of 0.28. Is there any risk?

The free/total PSA ratio is a parameter widely used by urologists to identify men with a higher likelihood of being diagnosed with prostate cancer.

Studies in the medical literature validated its results in men with PSA > 4 ng/ml, but urologists tend to use it from PSA levels > 2.5 ng/ml.

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When the free/total PSA ratio is below 20%, there is an approximately 25% chance of finding prostate cancer on biopsy.

To answer your question... a ratio above 28% is not, on its own, a parameter that leads to recommending a prostate biopsy.

The digital rectal exam, the rate of increase in total PSA and, more recently, prostate MRI are other parameters also widely used by urologists in the screening stage of the disease.

When at least one of these parameters is abnormal, a prostate biopsy is needed to reach a definitive diagnosis.

To learn more about PSA, watch this video: here

Dr. Bruno Benigno

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Dr. Bruno Benigno

Dr. Bruno Benigno
Urologist and uro-oncologic surgeon (CRM-SP 126.265 · RQE 60022). More than 1,500 robotic surgeries. Member of the AUA, EAU and SBU. Meet Dr. Bruno · In the Media

This content is educational and does not replace a medical consultation. Each case must be assessed individually, based on AUA, EAU and NCCN guidelines.

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